Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Hydroxychloroquine and Calcium Supplement

Research Papers that Mention the Interaction

In isolated human neutrophils, treatment with hydroxychloroquine resulted in reduced mobilisation of intracellular calcium , diminished concentration of external oxidants and in decreased phosphorylation of Ca(2+)-dependent protein kinase C isoforms PKCα and PKCβII, which regulate activation of NADPH oxidase on plasma membrane.
International immunopharmacology  •  2015  |  View Paper
In contrast, within 5 days 400 mg of hydroxychloroquine daily lowered elevated levels of calcium and 1,25-(OH)2D by 37% and 72%, respectively, in a hypercalcemic patient with sarcoidosis.
The Journal of clinical endocrinology and metabolism  •  1999  |  View Paper