Possible Interaction: Hydroxocobalamin and Vitamin C

“CONCLUSION Our preclinical data suggest that the novel synergism of hydroxocobalamin with ascorbic acid has the potential to extract CO through conversion to CO2, independently of high-flow or high-pressure O2.”

“It has been found previously that vitamin B12b amplifies significantly the cytotoxic effects of ascorbic acid by catalyzing the formation of reactive oxygen species, and the antioxidant dithiothreitol (DTT), in contrast to catalase, does not prevent the cytotoxicity.”

“It has been found previously that hydroxycobalamine (vitamin B12b) amplifies significantly the cytotoxic effect of ascorbic acid (vitamin C) added to cells for small a, Cyrillic long period of time (48 h).”

“The combination of hydroxocobalamin (vitamin B12b) and ascorbicacid (vitamin C) can cause the death of tumor cells at the concentrationsof the components at which they are nontoxic when administeredseparately.”

“The fact that hydroxocobalamin is readily destroyed in solutions containing ascorbic acid while cyanocobalamin is relatively stable in such solutions has been used as the basis of a procedure to determine hydroxocobalamin in the presence of cyanocobalamin.”