supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Hydroxocobalamin
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“All patients showed a sustained increase of baseline cobalamin concentrations 1 week after prior intranasal application of hydroxocobalamin.”
Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients.“In the normal status group, the test was performed with … (n = 28), or with 9 µg cyanocobalamin and 9 µg hydroxocobalamin (n = 14).ResultsIn both … after intake of cyanocobalamin compared to (hydroxocobalamin) [low status: 1.5 µg: 19 (6); …: 30 (14); normal status: 9 µg: 30 (13) pmol/L].”
“For equivalent doses of the 2 forms, the retention of a dose of cyanocobalamin is only approximately one-half as much as hydroxocobalamin (5).”
“ Hydroxocobalamin therapy increased serum vitamin B12 concentrations 14-fold (p < 0.001) and reduced plasma tHcy by 23% from 29.7 +/- 2.9 to 22.8 +/- 2.5 micromol/L (p < 0.01); serum methylmalonate decreased by one-third (p < 0.05).”
“ Unlabeled cyanocobalamin and hydroxocobalamin competitively inhibited the binding of cyano[57Co]cobalamin to this antibody.”
“By exploiting the differential binding of CN-Cbl and OH-Cbl , we developed a rapid and specific assay to accurately measure B12 levels in purified protein.”
Hydroxocobalamin association during cell culture results in pink therapeutic proteins“ Hydroxocobalamin increased significantly hepatic concentration of cobalamin 28 days after treatment, while CNB12 did not increase liver levels relative to pre-treatment (p < .05).”
“ Hydroxocobalamin increased significantly hepatic concentration of cobalamin 28 days after treatment, while CNB12 did not increase liver levels relative to pre‐treatment (p < .05).”
A pilot study comparing the pharmacokinetics of injectable cyanocobalamin and hydroxocobalamin associated with a trace mineral injection in cattle“After five, three-weekly injections of hydroxocabalamin liver vitamin B12 levels were significantly higher (p<0.01) than for the other treatments, with the exception of cobalt sulphate.”
“ Cyanocobalamin partially inhibited CO formation from hydroxocobalamin.”
“Less severe reactionsare urticaria coming on some hours after the injection of vitamin B12.3 It is highly probable that a patient sensitive to cyanocobalamin will also be sensitive to hydroxocobalamin , since the former is readily and rapidly converted to hydroxocobalamin.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback