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Possible Interaction: Hydroxocobalamin and Nitric Oxide

Research Papers that Mention the Interaction

Again, trapping NO with HCB blocked HO-2 inactivation.
European journal of biochemistry  •  1999  |  View Paper
The NO0 scavenger hydroxocobalamin blunted NO release.
Nitric oxide : biology and chemistry  •  2019  |  View Paper
Hemoglobin, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazolinel-oxyl-3-oxide, and hydroxo-cobalamin inhibited the relaxation to NO , but not to EFS and nitroglycerin in the presence of DETCA.
Acta Pharmacologica Sinica  •  2008  |  View Paper
The NO· scavengers, carboxy‐PTIO, (2‐(4‐carboxyphenyl)‐4,4,5,5‐tetramethyl‐imidazoline‐1‐oxyl‐3‐oxide; 100 μM) and hydroxocobalamin (100 μM), both inhibited responses to NO gas solution and to the three NO donor drugs, but not Angeli's salt.
British journal of pharmacology  •  2001  |  View Paper
Hydroxocobalamin (10−4 M) inhibited relaxations to NO by 50%, but not the electrically induced responses.
British journal of pharmacology  •  2000  |  View Paper
In endothelium-denuded guinea-… basilar artery preparations, hydroxocobalamin (30, 100 and 300 microM) concentration-dependently … the vasodilator responses to exogenous nitric oxide ( NO ), whereas the vasodilator responses to nitrergic nerve stimulation were slightly reduced by high (… and 300 microM) but not by the low (30 microM) concentration of hydroxocobalamin.
European journal of pharmacology  •  1997  |  View Paper
6 Hydroxocobalamin (5–1000 μm) inhibited, equally, relaxations to both NO (‐logIC40 3.14 ± 0.33) and nitrergic stimulation (‐logIC40 3.17 ± 0.22).
British journal of pharmacology  •  1996  |  View Paper
1 In organ bath experiments, hydroquinone (30–100 μm) and hydroxocobalamin (30–100 μm) concentration‐dependently inhibited the relaxations induced by NO (0.3–30 μm) but not those by nitroglycerin (GTN, 1 μm) in the canine ileocolonic junction (ICJ).
British journal of pharmacology  •  1995  |  View Paper
The cobalt atom of hydroxocobalamin (OHC) binds cyanide and nitric oxide (NO) and OHC attenuates vascular responses to NO in vitro.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
In longitudinal strips of rat gastric fundus, hydroxocobalamin (30 microM) significantly reduced relaxations to sodium nitroprusside (100 nM), nitric oxide (NO; 5 microM) and S-nitrosocysteine (3 microM), whereas responses to non-adrenergic, non-cholinergic (NANC) nerve stimulation were only slightly reduced.
European journal of pharmacology  •  1995  |  View Paper
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