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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydroquinone
supplement:
Vitamin K
Research Papers that Mention the Interaction
“Absorption and hepatic accumulation of long chain menaquinones seem to be restricted to a maximum, whereas also the lipophilic nature of long chain menaquinones may hamper the quinone-quinol reduction in anticoagulated animals.”
Induction of prothrombin synthesis by K-vitamins compared in vitamin K-deficient and in brodifacoum-treated rats.“Pre-steady-state reduction … bc(1) complexes with menadiol … quinol is not oxidized through center P but is oxidized through center N. In addition, the levels of stigmatellin and UHDBT … markedly diminished, while antimycin binding is unaffected, in the bc(1) complexes with Rieske proteins lacking the disulfide bridge.”
Elimination of the disulfide bridge in the Rieske iron-sulfur protein allows assembly of the [2Fe-2S] cluster into the Rieske protein but damages the ubiquinol oxidation site in the cytochrome bc1 complex.
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