“The elevated expression levels of Nrf2 and other antioxidant genes driven by hydroquinone were downregulated by SAC addition.”
“When cells were pre-treated with SAC , cell proliferation was dramatically enhanced whereas apoptosis was mitigated, and the ROS generation induced by hydroquinone was also significantly suppressed, indicating a prominent function of SAC in preventing ARPE19 cells from oxidant-related apoptosis.”