Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Hydroquinone and Cupric Cation

Research Papers that Mention the Interaction

This was supported by slight increase or decrease of cytotoxicity of HQ in the presence of Cu2+ and Fe3+, respectively.
Anticancer research  •  2000  |  View Paper
In contrast, among free metals, only Cu(II) strongly mediated the oxidation of HQ to BQ.
Molecular pharmacology  •  1996  |  View Paper
In previous studies, we observed that Cu(II) strongly induces the oxidation of hydroquinone (HQ), producing benzoquinone and H2O2 through a Cu(II)/Cu(I) redox cycle mechanism.
Using ESR spectroscopy, it was observed that Cu(II) strongly mediated the formation of semiquinone anion radicals from HQ in PBS, which could be blocked by BCS.
Chemico-biological interactions  •  1995  |  View Paper
By observing the kinetics of … from mixing 100 microM HQ … Cu(II ), it was found that all of the Cu(II) was reduced to Cu(I) within 5 s, followed by … and the generation of BQ, which reached maximum levels at 4 min after mixing HQ and Cu(II).
In phosphate-buffered saline, HQ underwent autoxidation slowly to BQ, while the presence of Cu(II) ions (1, 2.5, 5, 10, 50 microM) strongly accelerated the oxidation of HQ to BQ in a concentration-dependent manner.
The above results indicate that Cu(II) strongly induces the oxidation of HQ and as such may be a factor involved in the oxidative activation and toxicity of HQ in target cells.
The enhanced cytotoxicity of HQ by Cu(II) could be completely prevented by adding BCS, glutathione (GSH), or dithiothreitol but not by catalase.
Archives of biochemistry and biophysics  •  1993  |  View Paper
Structure-activity analysis shows that in the presence of Cu(II) , the DNA cleaving activity for phenolic compounds with a 1,4-hydroquinone structure, such as 1,2,4-benzenetriol and tert-butylhydroquinone is greater than those with a catechol group (catechol, 2-hydroxyestradiol and caffeic acid).
Cancer research  •  1994  |  View Paper
In a previous study, we observed that Cu(II ) strongly mediates the oxidation of hydroquinone (HQ) producing benzoquinone (BQ) and H2O2 through Cu(II)/Cu(I) redox mechanism.
When DNA pretreated with Cu(II) was exposed to HQ , DNA strand breaks were formed that could be prevented by BCS or catalase, indicating that DNA-bound copper can undergo redox cycling in the presence of HQ, generating H2O2.
Carcinogenesis  •  1993  |  View Paper