Possible Interaction: Hydrogen Peroxide and Vitamin E

“This study demonstrated in vitro and ex vivo that vitamin E inhibits collagen-induced platelet activation by blunting hydrogen peroxide formation.”

“Daily supplementation with 20 mg/kg vitamin E intramuscularly during the first 3 days of life was associated with a rise in plasma vitamin E concentration and a reduction in hydrogen peroxide haemolysis of red blood cells in vitro.”

“Analysis of Bcl-2/Bax ratio as ‘…’ showed that both pretreatment of γT3 and αT … H2O2 increase the ‘survival index’ of Bcl-2/Bax ratio compared to H2O2-treated cells, while treatment of … alone decrease the ratio compared to unchanged Bcl2/Bax ratio of similar treatment with αT alone.”

“Cellular uptake of γT3 was higher than that of αT. Treating cells simultaneously with either γT3 or αT and with then H2O2 led to higher expression of Bax and Bcl-2 than in neurons exposed to H2O2 alone.”

“The addition of alpha /- tocopherol (1 microM) inhibited cell proliferation in adipocytes treated with either H2O2 or high glucose, indicating that ROS plays a major role in the regulation of cell proliferation in adipocytes.”

“Supplementation with docosahexaenoic acid or α‐tocopherol significantly reduced oxidative damage from H2O2 or hyperoxia, but not that induced by paraquat.”

“Importantly, quercetin and vitamin E , two antioxidant agents, successfully prevent the premature senescent phenotype and the up-regulation of caveolin-1 induced by hydrogen peroxide.”

“Lignin biopolymer and vitamin E exhibited a protective effect against the overall DNA damage induced after H2O2 treatment.”

“c) Pre-treatment of hamster V79 and human CaCo2 cells with vitamin E significantly reduced the number of breaks induced by hydrogen peroxide , but has no effect on the level of breaks induced by MNNG or MMS.”

“Supplementation with alpha-tocopherol inhibited single-strand breaks induced by low concentrations of H2O2 only, whereas an adequate selenium supply almost completely inhibited single-strand breaks induced by up to 30 microM H2O2 and also significantly reduced H2O2-induced cell death.”

“HepG2 cells treated with H2O2 had significantly higher migration and invasion capabilities than the untreated control cells, and this aggressiveness was significantly inhibited by TA and SAM.”