Possible Interaction: Hydrogen Peroxide and Vitamin C

“A recent report indicates that vitamin C facilitates the decomposition of hydroperoxides in vitro, generating reactive aldehydes.”

“ResultsThe decoctions did not interact with H2O2, but quenched DPPH although less effectively than vitamin C. In contrast, vitamin C was significantly less effective in protecting human gastric epithelial cells (AGS) from apoptosis induced by DPPH, peroxynitrite and H2O2 (P < 0.001).”

“These findings and the results that show direct oxidation of ascorbic acid in the presence of peroxidase and H2O2, but not with H2O2 alone, support the conclusion that ascorbic acid released from cells may detoxify H2O2 by regenerating the catalytically active state of peroxidases.”

“100 microM AA added simultaneously with H2O2 to the cell medium enhanced the killing of PBMC but not of PM independently of the presence of Fe(2+)-EDTA.”

“Results It was observed that H2O2 significantly induced DNA damage in the lymphocytes and this damage was decreased significantly with Vit C and DEX.”

“Intravenous high-dose vitamin C (IVC) triggers the formation of hydrogen peroxide (H2O2), which contributes to Fenton chemistry producing hydroxyl radicals (-OH), causing selective damage to DNA.”

“A moderate negative correlation was found between serum levels of vitamins C and E and O2–•, HO•, H2O2 , NO•, and ONO•, reflecting a negative impact of elevated RONS levels on the endogenous antioxidant status.”

“ Ascorbic acid decreased H2O2 production although it generated H2O2 itself, in the absence of other additives.”

“However, when AA present in the system, it can consume part of H2O2 and hydroxyl radicals to inhibit the generation of o-benzoquinone, resulting in fluorescence recovery.”

“Conclusion: Vitamin C could effectively inhibit the eryptosis contributed by H2O2 oxidative stress, and the suppression on eryptosis with G6PD normal activity was more effective than that with G6PD deficiency.”