Possible Interaction: Hydrogen Peroxide and Ubiquinone

“ Coenzyme Q10 has a central role acting as a prooxidant in the generation of H2O2.”

“We previously demonstrated that hydrogen peroxide enhanced CoQ10 levels, whereas disruption of mitochondrial membrane potential by a chemical uncoupler suppressed CoQ10 levels, in human 143B cells.”

“However, H2O2 and FCCP both increased mRNA levels of multiple COQ genes for biosynthesis of CoQ10.”

“It is therefore believed that CoQ10 prevented the collapse of the mitochondrial membrane potential in response to the H2O2 treatment.”

“Ubiquinol‐10 inhibited reactive oxygen species (ROS) generation in cells exposed to α‐TOS, and a mitochondrially targeted coenzyme Q analogue also blocked apoptosis triggered by α‐TOS or hydrogen peroxide.”

“Moreover, CoQ10 significantly decreased RANKL‐induced osteoclastogenesis regardless of exposure to H2O2.”

“This study demonstrated that CoQ10 treatment was able to reduce levels of oxidative stress markers, such as H2O2 , acting as an antioxidant, as well as decreasing abnormal intracellular calcium influx in dystrophic muscles cells.”

“Furthermore, pre-incubation of the cells with CoQ10 also restored the activity of cellular antioxidant enzymes which had been altered by H2O2.”

“Pre-treatment of cells with CoQ10 diminished intracellular generation of ROS in response to H2O2.”

“ CoQ potentiated H2O2 release from antimycin A- or high Ca(2+)-treated mitochondria, but was capable of inhibiting lipid peroxidation and large amplitude swelling, and attenuated cytochrome c release from the mitochondria.”

“Pretreatment with CoQ improved BK-induced vasorelaxation after I/R (+12% +/- 2%; p < 0.05 versus control I/R) or H2O2 infusion (18% +/- 4%; p < 0.05 versus control I/R) but failed to improve SNP-induced vasorelaxation.”