Possible Interaction: Hydrogen Peroxide and Tretinoin

“In this article, we describe that RA strongly inhibits hydrogen peroxide (H(2)O(2))-induced apoptosis of mesangial cells by intervention in activator protein 1 (AP-1).”

“In addition, we show that tretinoin prevents the cytotoxicity of H2O2 in cultured human MCs by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes.”

“On the contrary, in ATRA differentiated cells treated with H2O2 , Bach1 displacement was impaired, preventing Nrf2 binding and limiting HO-1 transcription.”

“While undifferentiated cells were basically resistant to the oxidative stimulus, ATRA treatment progressively decreased cell viability in response to H2O2.”

“Antioxidant actions of retinoids have been attributed to chain-breaking by scavenging of peroxyl radicals.”

“ RA was found to inhibit the O2- and H2O2 production in a dose-dependent manner.”

“Increased cleavage of SREBP-1a by H2O2 was also observed even in the presence of RA.”

“ All-trans-retinoic acid (t-RA) inhibits hydrogen peroxide (H2O2)-induced apoptosis by inhibiting the c-Jun N-terminal kinase (JNK)-activator protein 1 (AP-1) pathway.”

“Preincubation with tretinoin abolished cell proliferation or cell death induced, respectively, by low and high concentrations of H2O2.”

“These results suggest that the modulation of the cellular actions of H2O2 may be relevant in the mechanisms through which tretinoin prevents age-related renal changes.”

“Prior treatment of B16 melanoma … or C6 glioma cells with all-trans-retinoic acid (0.1 microM) for a short time period (15 to 60 min) followed by subsequent treatment with oxidants such as hydrogen peroxide resulted in a 30 to 70% decrease in the oxidative modification of PKC.”

“However, treatment with retinoic acid enhanced the survival of PC12 cells following oxidative injury generated by H2O2 treatment in a manner that is qualitatively similar to that observed after nerve growth factor treatment.”