Possible Interaction: Hydrogen Peroxide and Taurine

“These results indicated that taurine exhibited anti-OA effect by alleviating H2O2 induced ER stress and subsequently inhibiting chondrocyte apoptosis.”

“Incubation with taurine resulted in lower intracellular pyruvate and α-ketobutyrate levels, decreased O2− and H2O2 formation and a concomitant significantly increased MPO activity.”

“We conclude that hydrogen peroxide and peroxynitrite may be involved in the DHA-induced increase in paracellular permeability and that the protective role of taurine may be in part related to its capacity to counteract the effects of hydrogen peroxide.”

“ Taurine led to an increased release of MPO and concomitant significantly reduced O2 − and H2O2 levels.”

“Thus, our results show that Tau protects myocardial cells against damage caused by H2O2 exposure, suggesting that it might play a role in the mitochondrial apoptotic pathway by upregulating the expression of CaMKII to rescue myocardial cells.”

“Moreover, taurine prevented NaF-induced increase in hydrogen peroxide and lipid peroxidation levels but increased acetylcholinesterase and the antioxidant enzymes activities in the hypothalamus, cerebrum and cerebellum of the rats.”

“Additionally, taurine inhibited fluoride-induced renal oxidative damage by markedly decreasing the hydrogen peroxide and malondialdehyde levels as well as improved the kidney architecture in the treated rats.”

“ Tau , but not Cys, Gly and Met, inhibited, by as much as 70%, insulin-mediated H2O2 pool increase.”

“Taurine-treated slices exposed to H2O2 showed no change in IOS; however, taurine efflux increased by 335±178%.”

“Furthermore, taurine was also found to suppress up-regulation of GRP78, GADD153/CHOP and Bim induced by H2O2 , suggesting that taurine may also exert a protective function against oxidative stress by reducing the ER stress.”