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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“In models of neurotoxicity, SFN has been shown to suppress neurotoxicity induced by a wide range of toxic factors, such as hydrogen peroxide , prion protein, hyperammonemia, and methamphetamine.”
“Both hydrogen peroxide and sulforaphane pretreatment reduced ROS production, increased the expression of Nrf-2, and decreased the expression of Runx2 following calcification.”
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway“Furthermore, SFN reduced the levels of intracellular hydrogen peroxide (P<0.01) and superoxide anion (P<0.05).”
“Manipulation of levels of GSH and Nrf2 in HepG2 cells confirmed that both molecules mediate the protective effects of SFN against H2O2.”
“The cells were treated with SFN at … for 30 min before a challenge with H2O2 for an additional …. Pretreatment with SFN reduced the secretion of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-… well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.”
“Moreover, 1–10 μM sulforaphane reduced the MN frequency induced by EMS, VIN, H2O2 and MMC in at least one of the treatment protocols; it had no effect on H2O2–MN induction in the post‐treatment protocol, and it increased MN induction by MMC in the pre‐treatment protocol.”
“Other mechanisms are involved in the anti‐genotoxic activity of sulforaphane against VIN and H2O2.”
“Furthermore, sulforaphane pretreatment prevented intracellular accumulation of reactive oxygen species (ROS) after exposure of the cells to XO/xanthine, H2O2 , or SIN-1.”
Potent Induction of Total Cellular and Mitochondrial Antioxidants and Phase 2 Enzymes by Cruciferous Sulforaphane in Rat Aortic Smooth Muscle Cells: Cytoprotection Against Oxidative and Electrophilic Stress“ SFN was found to ameliorate cellular damage caused by H2O2 and inhibited intracellular reactive oxygen species production.”
Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR-34a/SIRT1 axis by upregulating nuclear factor erythroid-2-related factor 2“Results showed that SFN and PEITC were able to counteract ROS production induced by H2O2.”
“Preincubation of ECFCs with SFN reduced intracellular ROS in the presence of H2O2 and preserved scratch-wound closure and tubule-formation.”
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