Possible Interaction: Hydrogen Peroxide and Selenium

“Both LA and LA-Plus synergised with selenium in inhibiting H2O2 induced NF-kappaB activation.”

“First, selenium in glutathione peroxidase may control intracellular levels of hydrogen peroxide , which affect the formation of active oxygen metabolites that may serve as initiators of lipid peroxidation; this role of selenium is closely related to that of superoxide dismutases, which control intracellular levels of the superoxide anion.”

“ Selenium pretreatment reduced intracellular ROS generation stimulated by H2O2 in cultured orbital fibroblasts of patients with GO.”

“The effects of H2O2 were counteracted by selenium , which also caused a reduced release of hyaluronic acid [3].”

“When performing the experiments of our previous study, we observed casually that selenium seemed to counteract also the cytotoxic action of H2O2.”

“ Selenium is involved in the metabolism of hydrogen peroxide and lipid hydroperoxides.”

“Selenium Se ), an essential trace element in human nutrition, is thought to have an important role in the prevention of oxygen damage by organic hydroperoxides generated by oxidative metabolism.”

“In addition, Se decreased the contents of MDA and H2O2 and increased the activities of CAT, SOD, GST, GSH and GSH-Px, alleviating the imbalance of the redox system induced by Cd.”

“A low dose of 5 ng/mL selenium induced a significant decrease in macrophage NO production, but significant increase in hydrogen peroxide (H2O2) levels (respectively, p = 0.009, p < 0.001).”

“The NO … and H2O2 levels were significantly increased … increasing concentrations of selenium ; the optimal macrophage activity levels were reached at 20 ng/mL. The concentration of 5 ng/mL of selenium induced a significant decrease in the bacterial arginase activity but a significant increase in the macrophage arginase activity.”

“When lymphocytes were pretreated with Se before treated with H2O2 , the Bax/Bcl-2 ratio and mRNA expression of those genes were significantly decreased, and Bcl-2 was increased (P < 0.05).”

“In liver tissue, the content of hydrogen peroxide was lower than that of controls in the 0.48–0.50 mg Se kg−1 groups, and the malondialdehyde level was lowest in the 0.48 mg Se kg−1 group.”