Possible Interaction: Hydrogen Peroxide and Rutin

“These finding suggests that rutin ; a nutritional compound can reduce oxidative stress induced by H2O2 by increasing the expression of Nrf2 and endogenous antioxidant enzymes.”

“Furthermore, rutin was found to prevent hydrogen peroxide from impairing relaxation of human chorionic plate placental vessels, which may help to protect endothelial function.”

“Lastly, rutin blocked the activation and translocation of NF-кB/p65 induced by H2O2.”

“Unscheduled DNA synthesis after removal of H2O2 was also markedly decreased by quercetin and rutin.”

“Moreover, CdE and rutin presented H2O2 scavenging activity with H2O2 levels reduction of 41 ± 7% and 46 ± 6%, respectively and SOD-like activity of 60 ± 4% and 51 ± 14%, respectively.”

“In addition, rutin markedly increased antioxidant enzymes [superoxide dismutase (SOD) and catalase (CAT)] activity, and improved oxidative production [malondialdehyde (MDA) and H2O2 ] level to balance the oxidation and anti-oxidation systems in the heart.”

“Furthermore, 20μmol/L rutin significantly abrogated the decrease in levels of phosphoinositide 3-kinase (PI3K) and phosphorylated serine/threonine kinase (p-AKT) induced by H2O2.”

“Furthermore, A. saponaria or its constituents aloin and rutin reduced the oxidative stress induced by H2O2 in skin homogenates in vitro.”

“It was found that rutin induced generation of H2O2 , which in turn oxidized Hb rapidly.”