Possible Interaction: Hydrogen Peroxide and Resveratrol

“We found … with RSV significantly increased cell viability; increased expression levels of tight junction (TJ) proteins (claudin-1, occludin, and ZO-1); improved activities of superoxide … (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px); and decreased intracellular reactive oxygen species (ROS) levels and apoptosis induced by H2O2 (P < …).”

“Results showed that RES reversed the impaired autophagy induced by H2O2 , and this increased autophagic flux was confirmed by the addition of bafilomycin A1.”

“On the other hand, quenching of H2O2 by antioxidants, resveratrol (RSV), or N-acetylcysteine (NAC) effectively blocked TRPM2-mediated Ca2+ influx, decreased intracellular Ca2+ overload, and increased cell survival.”

“Additional research has shown protection in cells against hydrogen peroxide when treated with RSV.”

“Only the RSV derivative, piceatannol (PIC), showed protection against hydrogen peroxide mediated cytotoxicity; whereas, RSV enhanced hydrogen peroxide sensitivity at a 50 µM concentration; the remaining metabolites evaluated had little to no effect on survival.”

“Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells.”

“We evaluated the effect of trans-resveratrol on the production of free radicals in pig blood platelets and showed that resveratrol inhibited the production of different reactive oxygen species (O2*-, H2O2 , singlet oxygen and organic radicals) measured by the luminol-dependent chemiluminescence in resting platelets (P < 0.05).”

“ Resveratrol (50 μmol/L) treatment for 8 h could improve the changes caused by H2O2 , increase the survival rate of cells (P < 0.01), reduce the release of LDH, decrease the level of MDA, increase the level of SOD and CAT (P < 0.01).”

“The remarkably higher positive rate of senescence-associated β-galactosidase and increased intracellular ROS levels in the H2O2 treatment group were reversed by treatment with 10 µM RESV.”

“Furthermore, to the best of our knowledge, the present study is the first to demonstrate that resveratrol attenuates the expression of thrombosis‑associated markers induced by H2O2 , which may occur through the suppression of the MAPK signalling pathways, indicating a potential novel therapeutic approach to prevent venous thrombosis.”

“ Resveratrol also significantly inhibited the induction of phosphorylated (p)‑p38, P‑c‑Jun N‑terminal kinase and P‑extracellular signal‑regulated kinase by H2O2 , and these effects were attenuated by the MAPK pathway activators anisomycin and curcumin.”

“The results of this study suggested that resveratrol suppressed the expression of thrombosis-related markers (P-selectin, PSGL-1, and VWF) induced by H2O2 most probably through the SIRT1 signaling pathway.”