Possible Interaction: Hydrogen Peroxide and Proline

“Treatment of WM35 cells with proline significantly increased cell viability, diminished oxidative damage of cellular lipids and proteins, and maintained ATP and NADPH levels after exposure to hydrogen peroxide.”

“When amino acids that are core components of dentin proteins, such as proline and alanine, were added to H2O2 , the generation of * OH decreased, but there was no change when glycine was added.”

“Mechanistically, by RNA sequencing (RNA-seq) and pathway analysis, Pro was shown to exert a protective effect through H2O2 catabolic processes and apoptotic processes, especially oxidative phosphorylation (OXPHOS).”

“Statistically significant correlation were found between H2O2 and 210Po and LPO and proline in mussel samples.”

“ Proline has been shown to provide protection against various reactive oxygen species (ROS), such as hydrogen peroxide and hydroxyl radicals.”

“When hydrogen peroxide H2O2 ) was used to induce oxidative stress, addition of proline significantly improved sperm quality and reduced ROS levels.”

“Further, root dipping treatment of H2O2 to plants under stress and stress-free conditions enhanced accumulation of proline and activity of catalase, peroxidase, and superoxide dismutase, whereas production of superoxide radical (O2•¯) and H2O2 were decreased.”

“ H2O2 accumulation triggers proline production which can be associated with oxidative protection, NADP+ recovery and shikimate pathway stimulation.”

“In contrast, the proline concentration correlated with the applied H2O2 concentration and was higher at the end of the day in treated plants.”

“Oxidative stress markers: superoxide radical, hydrogen peroxide and malondialdehyde (lipid peroxidation) were enhanced by As(V) exposure, however, their levels were significantly diminished by an exogenous application of Pro.”