Possible Interaction: Hydrogen Peroxide and Polyphenols

“In this study, pretreatment with TPs markedly attenuated H2O2-elicited cell viability loss and mitochondrial dysfunction, suppressed the induced apoptosis and reduced the elevated levels of intracellular ROS and H2O2.”

“The results revealed that rosemary polyphenols autooxidation in culture medium generated H2O2 at different rates.”

“In TP group, the addition of TP significantly increased viability of cells, activity of Na+/K+ ATPase and SOD while LDH release, MDA content and concentration of H2O2 were significant decreased compared with the positive control group.”

“Optimal doses of TP (0, 60, 80, and 100 μg/mL) were evaluated by pretreatment of BMEC for 0, 2, 4, 6, … with 100 µg/mL of TP for 12 h, then challenged by 600 μM H2O2 for 6 h. Results revealed that after H2O2 … TP of 100 …) accumulation.”

“After H2O2 (600 µM per culture well) exposure, a concentration of TP of 100 µg/mL during a 12-h incubation increased cell viability, decreased intracellular reactive oxygen species accumulation, and increased the abundance of nuclear factor-erythroid 2-related factor 2 (NFE2L2).”

“All polyphenols showed a protective effect against H2O2-induced oxidative stress in enterocytes, when administered before or after H2O2.”

“ CP also upregulated the decreased Bcl-2 protein levels in H2O2 treated C6 cells.”

“ CP not only suppressed the expression of these proteins but also attenuated the phosphorylation induced by H2O2.”

“Cocoa polyphenol extracts (CPE) dose dependently attenuated hydrogen peroxide (H(2)O(2))-induced inhibition of GJIC in rat liver epithelial (RLE) cells.”

“The combined treatment of polyphenols with Cu2+ ions and with H2O2 demonstrates that the lowest dose of phenols (1 microM) can act as an antioxidant agent against used chemicals.”

“A variety of synthetic and dietary polyphenols protect mammalian and bacterial cells from cytotoxicity induced by hydroperoxides , especially hydrogen peroxide (H2O2).”