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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Methylselenocysteine
Research Papers that Mention the Interaction
“We found that H2O2 , an ROS, simultaneously induced MSC lineage commitment towards adipogenesis and away from osteogenesis at the functional as well as transcriptional level.”
Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions“Otherwise, Seleno-L-cystine increased hydrogen peroxide production from relatively low concentrations (100 nM) to a large increase at high concentrations.”
“ H2O2 challenge induced massive MSC cell death along with reduction of expression of proliferation marker Ki67 and survival-related genes Bcl-2 and Survivin.”
“A continuous exposure to sublethal concentrations of hydrogen peroxide (H2O2), ranging from 25 to 100 µM for 21 days, resulted in the complete inhibition of BM‐MSC osteogenesis.”
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