Possible Interaction: Hydrogen Peroxide and Melatonin

“The inhibitory effect of H2O2 was significantly blocked by simultaneous addition of melatonin.”

“ Melatonin treatment overcame the inhibitory effect of H2O2.”

“ Melatonin markedly inhibited hydrogen peroxide (H2O2)‐stimulated cytotoxicity, iNOS, and COX‐2 protein and mRNA expression, as well as the downstream products, NO and PGE2.”

“Supplementation of melatonin reduced hydrogen peroxide concentration and increased catalase activity in the ovary, delayed meiotic cell cycle progression in follicular oocytes as well as in ovulated eggs since extrusion of first polar body was still in progress even after ovulation and protected against clomiphene citrate-induced egg apoptosis.”

“Our results show that through stimulation of specific melatonin receptors, melatonin induced an overexpression of the antioxidant enzyme catalase and superoxide dismutase‐1 and increased the resistance of MSCs to hydrogen peroxide‐dependent apoptosis.”

“Thus, the product that is formed when melatonin detoxifies hydrogen peroxide , that is, N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine is an efficient scavenger, at least equivalent to melatonin itself.”

“Thus, melatonin scavenges a number of reactants including the hydroxyl radical (*OH), hydrogen peroxide (H(2)O(2)), nitric acid (NO*), peroxynitrite (ONOO(-)) and peroxynitrous acid (ONOOH).”

“Additionally, melatonin reportedly neutralizes hydrogen peroxide , singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid.”

“ Melatonin has been reported to scavenge hydrogen peroxide (H2O2), hydroxyl radical (HO·), nitric oxide (NO·), peroxynitrite anion (ONOO–), hypochlorous acid (HOCl), singlet oxygen (1O2), superoxide anion (O2–·) and peroxyl radical (LOO·), although the validity of its ability to scavenge O2–· and LOO· is debatable.”

“ Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical.”