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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Masoprocol
Research Papers that Mention the Interaction
“ NDGA reduced SodB activity and increased both H2O2 sensitivity and Mtz susceptibility.”
Helicobacter pylori and Pathogenesis“Previous studies have 1) demonstrated that exposure to atherogenic LDL levels causes heightened EC H2O2 production, 2) identified the reactive oxygen …, NADPH oxidase, in EC, and 3) shown that the specific NADPH oxidase inhibitor, apocynin, and non-specific NADPH oxidase inhibitors, NDGA and … H2O2 production increases in …-perturbed EC.”
“ Nordihydroguaiaretic acid , an inhibitor of the lipoxygenase pathway, significantly inhibited both hydrogen peroxide and arachidonic acid-stimulated c-Fos and c-Jun protein expression and AP-1 activity.”
“Additionally, NDGA increased H2O2 sensitivity of H. pylori and increased the metronidazole (Mtz) sensitivity.”
“It was also shown that NDGA (20 μM) attenuates cell death in the THP-1 cell line that is caused by treatment with either IAA or H2O2.”
“ NDGA attenuates toxicity, ROS production and the oxidative stress-induced decrease of CD33 expression secondary to IAA or H2O2 in human MNs.”
“The nordihydroguaiaretic acid and N-ethylmaleimide inhibited production of H2O2 , while sodium azide enhanced the process.”
“ NDGA in the presence of H2O2 had a pronounced haemolytic effect, which did not correlate with its ability to induce methaemoglobin formation, while P2 had a much lower haemolytic effect, but stimulated the oxidation of haemoglobin to a greater extent than NDGA.”
“Cycloheximide, Ca2+ antagonists, oxypurinol, diphenyliodonium, nordihydroguaiaretic acid , bromophenacyl bromide, antiinflammatory agents, and antihistamines block or decrease OA-stimulated HPx production.”
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.“Furthermore, the effect of hydrogen peroxide on c-jun mRNA was also reduced by NDGA , an inhibitor of the lipoxygenase-cytochrome P450 mono-oxygenase system, suggesting that metabolism of arachidonic acid through this pathway is required for the induction of c-jun mRNA by oxidants.”
“ Nordihydroguaiaretic acid (a lipoxygenase-cytochrome P450 monooxygenase inhibitor) significantly inhibited both hydrogen peroxide and arachidonic acid-induced c-fos mRNA expression, whereas indomethacin (a cyclooxygenase inhibitor) had no effect.”
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