Possible Interaction: Hydrogen Peroxide and Manganese

“In the presence of manganese and hydrogen peroxide , 5448ΔmntE mutant exhibits significantly lower survival than wild-type 5448 and the complemented mutant.”

“While exposure to H2O2 reduced the expression of Mn SOD in Chinese hamster lung fibroblast (V79‐4), the addition of butin restored Mn SOD expression at both the mRNA and protein levels, resulting in increased Mn SOD activity.”

“Recent evidence indicates that under in vitro conditions, superoxide anion and hydrogen peroxide (H2O2) are unstable in the presence of manganese ion (Mn2+).”

“Here, we show that accumulation of Mn also confers resistance to hydrogen peroxide killing via a catalase-independent mechanism.”

“ Mn stress significantly reduced the final leaf number and superoxide dismutase (SOD), catalase (CAT), … ascorbate peroxidase (APX) activities of V. natans, while increased the malondialdehyde (MDA), hydrogen peroxide (H2O2) and proline contents, and peroxidase (POD) activity, with no significant … in plant relative growth rate (RGR) and photosynthetic pigment contents.”

“The present study with intact mitochondria reveals that manganese additionally enhances H2O2 emission by inducing mitochondrial permeability transition (mPT).”

“The present … through which manganese … H2O2 emission: stimulating its production from distinct sites (e.g. site IIQ), accelerating superoxide dismutation and enhancing the emission via mPT which also … of soluble components of the mitochondrial antioxidant systems and favors the ROS production from flavin-containing oxidoreductases of the Krebs cycle.”

“Furthermore, the addition of manganese also led to a reduction in the amount of hydrogen peroxide produced by bacterial cells.”

“In microglia, Mn increases hydrogen peroxide (H(2)O(2)) release and potentiates lipopolysaccharide (LPS)-induced cytokines (TNF-α, IL-6) and nitric oxide (NO).”

“The mitochondrial membrane potential was also affected by manganese and rescued by GSH-EE, suggesting that H2O2 was also involved in the manganese damages to the mitochondrial membrane potential.”

“While the mechanism of this toxicity is currently unknown, it has been postulated that Mn may be involved in the generation of reactive oxygen species (ROS) through interaction with intracellular molecules, such as superoxide and hydrogen peroxide , produced within mitochondria.”