supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Hydrogen Peroxide
supplement:
Manganese Cation (2+)
Research Papers that Mention the Interaction
“ Mn(II)- or Cu(II)-catalyzed autoxidation of caffeic acid produced H2O2 with efficiency of Mn(II) greater than Cu(II).”
Caffeic acid causes metal-dependent damage to cellular and isolated DNA through H2O2 formation.“The presence … or Mn(II ) enhanced the … by hydrogen peroxide (H2O2) and Cu(II), and altered the site specificity of the latter: H2O2 induced Cu(II)‐dependent DNA damage with …′‐guanine of poly G sequences; when SODs were added, the frequency of cleavages at thymine and cytosine residues increased.”
Superoxide dismutases enhance H2O2‐induced DNA damage and alter its site specificity“The Mn(II) complex reacts with H2O2 to produce a more highly aquated Mn(II) species that exhibits a 130% greater r1, quadrupling the percentile response of our next best sensor.”
A Macrocyclic Ligand Framework That Improves Both the Stability and T1-Weighted MRI Response of Quinol-Containing H2O2 Sensors.“Like mrgA, transcription of the katA and hem genes is repressed by Mn(II) , which thereby potentiates the killing action of H2O2.”
“At physiological concentrations of HCO3- and CO2, Mn(II ) catalyzes disproportionation of H2O2.”
“In the presence of H2O2 the enzyme oxidizes Mn(II) significantly faster than it oxidizes all other substrates.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback