Possible Interaction: Hydrogen Peroxide and Lutein

“Cell death induced by H2O2 was significantly reduced after pre-treatment with curcumin and lutein , but not resveratrol.”

“Neonatal supplementation with lutein in the first hours of life increases BAP and reduces TH in supplemented babies compared to those untreated.”

“Pre-incubation with lutein , zeaxanthin, or α-tocopherol dramatically reduced the levels of H2O2 -induced protein carbonyl, MDA, and DNA damage in HLEC.”

“At 48 h of life, compared with those in the control group, neonates assigned to receive lutein had significantly lower TH levels (p = 0.04) and higher BAP levels (p = 0.028).”

“Moreover, Lut and GA prevented CoCl2-induced increases in hydrogen peroxide ( H2O2 ), malondialdehyde (MDA) and nitric oxide (NO) in the brain, while also restoring the activities of acetylcholinesterase, glutathione S-transferase (GST) and superoxide dismutase (SOD).”

“In this study, we demonstrated that lutein treatment attenuated the reduction in cell viability caused by H2O2.”

“Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies.”

“Our results show that the application of lutein suppressed the H2O2-induced ROS (10′: 7.5 ng + 10 µM H2O2 , p = 0.0002; 10 ng/µL + 10 µM H2O2, p = 0.0007), influenced iron utilization and changed the anti-inflammatory and pro-inflammatory cytokine secretions in BV-2 cells.”