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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“The fluorescent analysis also showed that the addition of H2O2 (0.5 mM) enhanced the cellular lipid peroxidation levels in LA and AA supplemented cells as compared with those without H2O2.”
Lipid Peroxidation of a Human Hepatoma Cell Line (HepG2) after Incorporation of Linoleic Acid, Arachidonic Acid, and Docosahexaenoic Acid“Furthermore, lesion and pure linoleic acid hydroperoxides were reduced to yield linoleic acid hydroxides.”
“However, we observed that traces of hydroperoxides present in a fresh solution of linoleic acid can promote lipid peroxidation and apo B oxidation, substituting H2O2.”
“In particular, CLA isomers and linoleic acid supplementation showed a better antioxidant cellular response against oxidative damage induced by H2O2 compared with other FA.”
Comparison between conjugated linoleic acid and essential fatty acids in preventing oxidative stress in bovine mammary epithelial cells.“The levels of NEFA (lauric, myristic, palmitoleic, arachidonic, linoleic , palmitic, oleic and stearic acids) increased after the treatment with H2O2.”
“Exposure of OK … 1.25 mM H2O2 for one hour resulted in more cell death (determined by … trypan blue assay) in cells grown in serum supplemented with linoleic acid with "normal" PUFA content (90 +/- 2%) than in cells with "…" levels of PUFA grown in unsupplemented calf serum (81 +/- 3%).”
“Styrene, arachidonic acid and linoleic acid reacted with the peroxyl radical, reducing its amplitude by 84, 57, and 35%, respectively, but did not decrease the amplitude of either radical species in the anoxic incubation.”
“It has been shown on … under the effect of linoleic acid hydroperoxides in vitro ionic permeability and membrane capacity of the cells sharply decrease after some threshold concentration of hydroperoxides (…), while the threshold value decreases with the increase of the time of cell incubation in the presence of hydroperoxides.”
“Under effects of linoleic acid hydroperoxides , the repression of DNA synthesis is enhanced.”
“ H2O2 at concentrations less than 1.0 nM stimulated linoleic acid oxidation synergistically and the magnitude of synergism was higher at pH 9.0.”
“ H2O2 in the presence of linoleic acid produced synergism in xenobotic metabolism and depending upon the substrate in question upto 11-fold increase in oxidation rate was noted.”
Dioxygenase and peroxidase activities of soybean lipoxygenase: synergistic interaction between linoleic acid and hydrogen peroxide.
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