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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Hydrogen Peroxide
supplement:
Leucine
Research Papers that Mention the Interaction
“ Hydrogen peroxide at 10 mg L −1 or higher had a detrimental effect on the moving phytoplankton and zooplankton.”
Elimination of cyanobacteria and microcystins in irrigation water—effects of hydrogen peroxide treatment“ H2O2 at a concentration higher than 0.75 mumol/L decreased I(Kur) and I(Ca, L).”
“The maximum current densities of I(Kur) and I(Ca L ) was significantly increased at lower H2O2 concentration, but was decreased at higher H2O2 concentration.”
“Blocking VGCC L , N, and P/Q subtypes decreased the number of cells and their calcium currents that respond to H2O2 The number of responder cells to H2O2 also decreased in the presence of dithiothreitol, suggesting the actions of H2O2 were dependent on sulfhydryl oxidation.”
H2O2 augments cytosolic calcium in nucleus tractus solitarii neurons via multiple voltage-gated calcium channels.“Conclusions: H2O2 induced afterdepolarizations via the activation of PKC and the enhancement of ICa, L and INa,L. These results provide evidence of a link between oxidative stress, PKC activation and afterdepolarizations.”
“ H2O2 (0.3 mM) inhibited ICa, L by 13%, and additional rotenone induced an increase with a negative shift.”
“In the presence of 50 μmol/L H2O2 , APD50 and APD90 shortened (P<0.01), amplitude of RMP decreased (P<0.05), the peak of ICa, L reduced significantly (P<0.05).”
“In whole-cell recording studies, H2O2 significantly enhanced the late Na+ current (INa, L ) and L-type Ca2+ current (ICa,L) in myocytes, which were dramatically suppressed or prevented by resveratrol.”
“ H2O2 significantly enhanced ICa, L by activating Ca2+/calmodulin-dependent protein kinase II, and subsequent addition of sevoflurane, isoflurane, or desflurane similarly reduced ICa,L to below baseline levels.”
“In the presence … mmol/L H2O2 , peak …, L was reduced significantly (P<0.001), the I-V curve of ICa,L was shifted upward, steady-state activation curve and … deactivation curve of ICa,L were shifted left and recovery time of ICa,L was delayed significantly (P<0.001).”
“However, when recorded under nystatin perforated patch configuration, H2O2 caused a gradual and significant increase (84 +/- 14%) in ICa, L compared to control values.”
“Thus, our results demonstrate a potent stimulatory effect of H2O2 on ICa, L in guinea pig ventricular myocytes.”
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