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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Hydrogen Peroxide and Idebenone

Research Papers that Mention the Interaction

In addition, idebenone pretreatment significantly attenuated the induction of SA-β-Gal and intracellular ROS as well as the amount of histone-associated DNA fragments after treatment with H2O2.
When cells were treated with H2O2 , pretreatment with 5, 7.5, 10, and 20 µM idebenone led to a significant increase in the viability of ARPE-19 cells.
Ophthalmologica  •  2015  |  View Paper
In addition, idebenone pretreatment significantly attenuated the increase of histone-associated DNA fragmentation, induction of senescence-associated &bgr;-galactosidase, and intracellular reactive oxygen species after treatment with H2O2.
Pretreatment with 10 µM idebenone led to an increase in viability of ONHA after H2O2 treatment.
Journal of glaucoma  •  2013  |  View Paper
Idebenone treatment modestly elevated succinate-derived H2O2 production when compared to vehicle control (1.34 ± 0.05 vs 1.21 ± 0.05%, H2O2/O2 respectively, P < .05).
Journal of molecular and cellular cardiology  •  2019  |  View Paper
Likewise, idebenone inhibits microsomal lipid peroxidation induced by ADP-iron complexes or organic hydroperoxides.
Chemical research in toxicology  •  1998  |  View Paper