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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Idebenone
Research Papers that Mention the Interaction
“ Idebenone treatment modestly elevated succinate-derived H2O2 production when compared to vehicle control (1.34 ± 0.05 vs 1.21 ± 0.05%, H2O2/O2 respectively, P < .05).”
Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury.“In addition, idebenone pretreatment significantly attenuated the induction of SA-β-Gal and intracellular ROS as well as the amount of histone-associated DNA fragments after treatment with H2O2.”
“When cells were treated with H2O2 , pretreatment with 5, 7.5, 10, and 20 µM idebenone led to a significant increase in the viability of ARPE-19 cells.”
“In addition, idebenone pretreatment significantly attenuated the increase of histone-associated DNA fragmentation, induction of senescence-associated &bgr;-galactosidase, and intracellular reactive oxygen species after treatment with H2O2.”
“Pretreatment with 10 µM idebenone led to an increase in viability of ONHA after H2O2 treatment.”
“Likewise, idebenone inhibits microsomal lipid peroxidation induced by ADP-iron complexes or organic hydroperoxides.”
Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone).
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