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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Hydrogen Peroxide
supplement:
Hydroxytyrosol
Research Papers that Mention the Interaction
“In the presence of H2O2, hydroxytyrosol showed to significantly protect RBCs from oxidative hemolysis in a dose-dependent manner, but the hydroxytyrosol glucuronides showed only a limited protection that was independent of the concentration used.”
Protective activity of hydroxytyrosol metabolites on erythrocyte oxidative-induced hemolysis.“ Hydroxytyrosol led to lower levels of hydroperoxides , DNA damage, and mRNA levels of classic glutathione peroxidase (GPx) for all the studied concentrations.”
“Early research has revealed that HT can activate the silent information regulator 1 (SIRT1) pathway to induce autophagy and alleviate the cartilage inflammatory response caused by H2O2.”
Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response.“Incubation of VECs with HT prevented the increase in intracellular reactive oxygen species levels in the presence of H2O2.”
“ Hydroxytyrosol exerted a significant antioxidant action, inhibiting the production of MDA, fatty acids hydroperoxides and 7-ketocholesterol, major oxidation products of unsaturated fatty acids and cholesterol, and thus protecting the cells from H2O2-induced damage.”
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