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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Hydrogen Peroxide
supplement:
Heme Iron
Research Papers that Mention the Interaction
“As a consequence, it prevents the binding of H2O2 to heme iron.”
First structural evidence for the mode of diffusion of aromatic ligands and ligand-induced closure of the hydrophobic channel in heme peroxidases“It is proposed that heme iron activates hydrogen peroxide to a more powerful oxidant, perhaps the hydroxyl radical, which remains bound to the heme iron and initiates attack on the porphyrin ring.”
“ Heme iron and nonheme dimanganese catalases protect biological systems against oxidative damage caused by hydrogen peroxide.”
Disproportionation of H2O2 Mediated by Diiron-Peroxo Complexes as Catalase Mimics“Competitive inhibition of the alkylhydroperoxide reductase activity by carbon monoxide has also been observed, thus confirming that heme iron is directly involved in the catalytic mechanism of hydroperoxide reduction.”
“We propose that the free space size in the vicinity of the heme iron significantly influences P450BM-3 H2O2-supported activity and H2O2 inactivation.”
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