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Last Updated: 3 years ago

Possible Interaction: Hydrogen Peroxide and Genistein

Research Papers that Mention the Interaction

Genistein partially prevented the effects of H2O2 on Caco-2 cells suggesting a role for protein tyrosine phosphorylation in H2O2-induced epithelial barrier dysfunction.
Cellular and molecular biology  •  2003  |  View Paper
Of tested isoflavones, genistein is the most potent inhibitor among TPA-induced H2O2 formation by (dimethyl sulfoxide) DMSO-differentiated HL-60 cells, daidzein is second, and aplgenin and biochanin A show little effect.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1995  |  View Paper
Here we report that genistein , a soybean isoflavone, strongly inhibits tumor promoter-induced H2O2 formation both in vivo and in vitro.
In addition, genistein moderately inhibited superoxide anion formation by HL-60 cells and scavenged exogenously added H2O2 under the same conditions as in cell culture.
Nutrition and cancer  •  1993  |  View Paper
Genistein improved redox status of HeLa cells treated with H2O2 by lowering radicals' level.
Biochimica et biophysica acta  •  2014  |  View Paper
Genistein also prevented the inhibition of B-cell lymphoma 2 and the activation of caspase-3 induced by H2O2.
British Journal of Nutrition  •  2012  |  View Paper
Platelet‐activating factor (PAF) receptor antagonists, lovastatin, and the isoflavone protein tyrosine kinase (PTK) inhibitor genistein each reduced H2O2 secretion by Macs maintained on oxLDL‐containing matrices by ∼60%.
Journal of leukocyte biology  •  2005  |  View Paper
Here we show that genistein decreases NF-kappa B DNA binding and abrogates NF-kappa B activation by DNA-damaging agents, H2O2 and tumor necrosis factor-alpha, in prostate cancer cells regardless of androgen sensitivity.
Nutrition and cancer  •  1999  |  View Paper
The tyrosine kinase inhibitor genistein was able to block platelet aggregation induced by H2O2 and NaVO4, thus confirming that tyrosine kinase activity was needed to trigger alphaIIbbeta3 activation on stirring.
Arteriosclerosis, thrombosis, and vascular biology  •  1998  |  View Paper
Similar to the effect on TGF-β1-induced H2O2 production, phosphorylation of these proteins was blocked by the addition of actinomycin D. The protein-tyrosine kinase inhibitors genistein and herbimycin A inhibited TGF-β1-induced protein tyrosine phosphorylation, NADH oxidase activation, and H2O2 production in a dose-dependent manner.
The Journal of Biological Chemistry  •  1998  |  View Paper
The results indicated that genistein was the most potent inhibitor of H2O2 production by TPA-stimulated HL-60 cells, followed by apigenin and daidzein, whereas prunectin and biochanin A exhibited no effect.
Nutrition and cancer  •  1997  |  View Paper
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