Possible Interaction: Hydrogen Peroxide and Ferrous

“However, the redox cycling of ferrous and ferric iron in the presence of H2O2 , which is physiologically present in the cells, also leads to the production of free radicals (Fenton reaction) that can attack and damage lipids, proteins, DNA, and other cellular components.”

“ Ferrous iron can react with hydroperoxides , via a Fenton-type reaction, to initiate free radical chain processes.”

“However, the exposure of cells to hydrogen peroxide before the addition of ferrous iron did not increase cellular radical formation, but actually decreased spin adduct formation.”

“A range of hydroperoxides were reduced by ferrous ions in acid solutions and the amount of ferric product was measured as a xylenol orange complex at 560 nm.”

“We found that the higher concentrations of ferrous iron (II) increase the inactivation of CD45, LAR and PTP1B phosphatase caused by hydrogen peroxide , but the addition of the physiological concentration (500 nM) of ferrous iron (II) has even a slightly preventive effect on the phosphatase activity against hydrogen peroxide.”

“One important reaction may be the interaction of ferrous iron Fe ) with H2O2 to generate hydroxyl radical ( dOH) (Fenton reaction).”

“ Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack.”

“We also show that caspase inhibition leads to increases in the levels of oxidized proteins obtained by treatments with hydrogen peroxide plus ferrous iron.”

“ Ferrous iron catalyses the formation of hydroxyl radicals (OH*) from hydrogen peroxide , known as the Fenton reaction (Fez+ + H,O, + Fe” + O H + OH-).”

“Ferrous sulfate (but not other more tightly coordinated ferrous ions , such as the complex with ethylenediamine tetraacetic acid) counteracts the inhibitory action of hydrogen peroxide on cytoplasmic aconitase, probably by replenishing iron at the active site.”