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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Ferrous Sulfate
Research Papers that Mention the Interaction
“ Hydrogen peroxide produced during iron oxidation can react with additional iron(II) at ferroxidase centers, or at separate sites, or possibly on the surface of the mineral core.”
Iron mineralization and Core dissociation in mammalian Homopolymeric H-ferritin: Current understanding and future perspectives.“Kinetic and mechanistic studies confirm that the low efficiency with which peroxidative processes occur depends on the limited rate of the reaction between hydrogen peroxide and the iron(III) center , to form the active species, and by the competitive peroxide degradation reaction.”
“ Ferrous sulfate (but not other more tightly coordinated ferrous ions, such as the complex with ethylenediamine tetraacetic acid) counteracts the inhibitory action of hydrogen peroxide on cytoplasmic aconitase, probably by replenishing iron at the active site.”
“When hydrogen peroxide plus iron sulfate was used as a strong oxidant in macrophages, GSH concentrations decreased as a result of cell injury.”
“The enzyme activity decreases by 50% within 30 minutes of incubation in the presence of 100 microM of hydrogen peroxide and 5 microM of ferrous sulfate.”
[Inactivation of AMP-deaminase from white muscle of Cyprinus carpio in the systems with free radical oxidation].“The incubation of additional adjacent sections with the prooxidant mixture H2O2 plus iron(II) , in order to induce the complete oxidation of lipid present in the section, showed a decreased basal concentration of oxidizable lipid substrate in GGT-rich areas.”
“Administration of H2O2 plus ferrous sulfate significantly elevated both pre-ischemic amino acid release and ischemia-evoked release.”
“Simultaneous addition of hydrogen peroxide (0.01%) and ferrous sulfate (100 microM) resulted in a >80% decrease in synaptic potentials recorded in the CA1 region of hippocampal slices of adult male rats.”
“Both processes result in enhanced production of hydrogen peroxide , which in the presence of iron(II) ions decomposes to the hydroxyl radical.”
“Similar effects were seen in small, but not in large, arterioles during topical application of hydrogen peroxide or hydrogen peroxide plus ferrous sulfate , a combination that produces free hydroxyl radical.”
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