Possible Interaction: Hydrogen Peroxide and Ferric Ion

“However, the redox cycling of ferrous and ferric iron in the presence of H2O2 , which is physiologically present in the cells, also leads to the production of free radicals (Fenton reaction) that can attack and damage lipids, proteins, DNA, and other cellular components.”

“The addition of dopamine or H2O2 oxidizes the ferrous iron of the native human TH to the ferric state.”

“Some carcinogenic metal compounds [chromate(VI), Fe(III) nitrilotriacetate , cobalt(II), and nickel(II)[ induced formation of various oxygen radical species in the presence of hydrogen peroxide.”

“Under such circumstances, the initially formed ferric state can react with H2O2 (or other peroxides) to generate a long-lived ferryl [Fe(IV)=O] Compound II (Cpd II) heme intermediate that is capable of oxidizing a variety of biomolecules.”

“The kinetic behavior for the reaction of both ferric proteins with H2O2 indicates that the rate for the formation of the ferryl intermediates species varies with pH, suggesting that the reaction is strongly dependent on the conformational states.”

“These results suggest that phenolic stilbenes act as antioxidants of membrane lipids and that resveratrol has a prooxidative effect DNA damage during interaction with ADP-Fe3+ in the presence of H2O2.”

“ Fe(III) ions in the two sites display different reactivity towards H2O2 , because only Fe(III) bound in the nucleotide-independent site rapidly reacts with H2O2 thus mediating a 30% enzyme inactivation.”

“The formation of Compound I is due to the reaction of ferric catalase with hydrogen peroxide , which is generated by the disproportionation of the superoxide anion (O-2).”

“Exposure of corneas to 20 mM H2O2 for 10 min in the presence of EDTA ‐ Fe+3 resulted in an enhancement of corneal swelling rate more rapid than that which resulted from a 10 min exposure to 20 mM H2O2 alone.”

“ Fe++ and a number of other heavy metal ions, as well as dipyridyl, lipoic acid, CoA—SH, and H2O2 generated in situ strongly inhibit it, whereas ascorbic acid, imidazole, aminopterin, and folic acid have little or no effect.”