Possible Interaction: Hydrogen Peroxide and Epigallocatechin Gallate

“The joint study of the transcriptome and proteome in liver found that EGCG exerted its effects mainly by regulating the suppression of hydrogen peroxide and oxygen species metabolism, suppression of oxidative stress, activation of fatty acid transport and oxidation and cholesterol metabolism.”

“Pretreatment with EGCG increased the stress sensitivity of MCF-7 cells upon heat shock (44°C for 1 h) or oxidative stress ( H2O2 , 500 μM for 24 h).”

“Furthermore, the decrease of cellular alpha-Toc content induced by exposure to H2O2 was prevented by the pretreatment of EGCG.”

“When the cells were preincubated with EGCG , the cytotoxicity of H2O2 was significantly reduced.”

“Our findings also suggest that EGCG treatment would provide anti-apoptosis, anti-inflammation and promote cell viability in H2O2 treatment-incubated NPCs through inhibiting cGAS/Sting/NLRP3 pathway.”

“Although hydrogen peroxide was produced by the autoxidation of EGCg , hydrogen peroxide itself had little effect on the ACE activity.”

“Auto-oxidation of EGCG generated a high level of hydrogen peroxide in the medium.”

“The incubation of human dermal fibroblasts with EGCG markedly inhibited the human dermal fibroblast injury induced by H2O2.”

“ EGCG in HL-60 cells acted as a pro-oxidant enhancing intracellular hydrogen peroxide significantly.”

“In the presence of low‐dose H2O2, EGCG induced apoptosis and abolished the cell‐proliferative effect exhibited by low‐dose H2O2.”

“Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H2O2 , both being inhibited by ERK and JNK inhibitors.”