Possible Interaction: Hydrogen Peroxide and Ebselen

“The hydrogen peroxide reductase activity of human thioredoxin reductase was stimulated 15-fold by 2 microM ebselen.”

“It is obvious that the biological functions of ebselen might extend to other reactions in addition to the reduction of hydroperoxides.”

“ Ebselen (20 microM) prevented the increase in nitrite production by rat islets exposed to IL-1 beta for 6 hr and induced significant protection against the acute inhibitory effects of alloxan or H2O2 exposure, as judged by the preserved glucose oxidation rates.”

“Scavenging H2O2 with ebselen treatment significantly reduced the expression of eight BCGresponsive genes, and inhibited the activation of a number of signalling molecules known to be downstream of BCG (NFκB, CEBP and NRF2) in urothelial cancer cells.”

“Similarly, pretreating cells with the potent H2O2 scavenger ebselen significantly reduced the production of H2O2, O2 – and NO compared with BCG alone, highlighting the importance of H2O2 generation in this system.”

“In agreement with this fact, ebselen , a GSH peroxidase mimic, abrogated the increase in NO toxicity induced by H2O2.”

“ Ebs was able to reduce the ROS formation and DNA damage caused by H2O2 in a concentration-dependent manner.”

“The results also demonstrate that ebselen was able to reduce the ROS formation and DNA damaging effect caused by H2O2 in a dose-dependent manner.”

“The results showed that H2O2 suppressed the growth of HepG2 cells and the addition of ebselen significantly reduced the suppression.”

“When a higher flux of aqueous peroxyl radicals was used, ebselen increased the observed inhibited phase of peroxidation in a dose-dependent manner, though less pronounced than its prolongating effect on the lag-phase of Cu(2+)-induced LDL lipid oxidation.”

“Antioxidants such as ascorbic acid and ebselen suppressed the release of cytosolic proteins induced by H2O2 treatment.”

“The decrease in hydrogen peroxide release was completely reversed by treatment with tempol, whereas treatment with ebselen caused a further decrease in hydrogen peroxide release in nitrate tolerant tissues.”