Possible Interaction: Hydrogen Peroxide and Cuprous

“… Cu(I) … hydrogen peroxide and re-reduction of Cu(II) by superoxide via Fenton and Haber-Weiss chemistry yields hydroxyl radicals that can damage proteins, lipids, and …, intracellular copper concentrations must be controlled such that copper ions are provided to essential enzymes, but do not accumulate to deleterious levels.”

“DNA damage was inhibited by catalase and bathocuproine, a Cu(I) chelator, suggesting that reactive species derived from the reaction of H2O2 with Cu(I) participate in DNA damage.”

“being further oxidized to NAD+ with generation of superoxide radical and that H2O2 reacts with Cu(I) to form active oxygen species such as copper(I)-peroxide complex causing DNA damage.”

“The ·OH generated in the reaction of Fe2 or Cu+ with H2O2 initiates lipid peroxidation, which results in oxidative damage of tissues.”

“The generated Cu+ and Ce3+ further reacted with local H2O2 to generate toxic hydroxyl radicals (˙OH) via the Fenton reaction.”

“Reduced metal ions Cu(I) and Fe(II)] interact with H2O2 , generated during the redox reaction, to produce Cu(I)OOH and OH that cause DNA damage, respectively.”

“ Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I) , which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack.”

“These results indicated that reactive oxygen species formed by the interaction of Cu(I) and H2O2 participates in the DNA damage.”

“DNA damage was inhibited by both catalase and bathocuproine, Cu(I)-specific stabilizer, suggesting that reactive species derived from the reaction of H2O2 with Cu(I) participate in DNA damage.”

“The order of the extent of damage to 32P-labeled DNA fragments by aminosugars plus Cu(II) was ManN >> GalN > GlcN. The DNA damage was inhibited by catalase and bathocuproine, suggesting that H2O2 reacts with Cu(I) to form the metal-peroxide complex capable of causing DNA damage.”