Possible Interaction: Hydrogen Peroxide and Cupric Cation

“The addition of H2O2 strongly promoted Cu-induced dityrosine cross-linking of Abeta1-28, Abeta1-40, and Abeta1-42, suggesting that the oxidative coupling is initiated by interaction of H2O2 with a Cu(II) tyrosinate.”

“The anti-microbial activity of cupric ions and hydrogen peroxide (H2O2) are well known however their combined application is not currently utilised as a decontamination agent in the tissue banking world sector.”

“When aggregates are prepared in the copresence of Cu(II) and Zn(II) ions, the ratio of Cu(II):Zn(II) becomes an important factor in the degeneration of H2O2 , the formation of carbonyl groups in the peptide, and in aggregate morphology.”

“The Aβ–Cu(II) complex has been shown to catalytically generate H2O2 from reducing agents and O2.”

“This method is based on hydroxyl radical chemiluminescence—the hydroxyl radical generated by reaction of Cu(II) and hydrogen peroxide oxidizes rhodamine B (RhB) to produce weak CL which can be enhanced by metformin.”

“At the same time, Cu2+ -induced significant increase of H2O2 and O2.- generation via a concentration- and time-dependent manner too.”

“Furthermore, H2O2 plus Cu(II) caused DNA damage, including 8‐oxodG formation, specifically at the GGG sequence in the telomere sequence (5′‐TTAGGG‐3′).”

“Incubation of synthetic human Abeta with Cu(II) , but not Fe(III), in the presence of H2O2 similarly induced a decrease in histidine residues (-79%), but also a decrease in tyrosine residues (-28%).”

“It was found that strong oxidants are generated from NO−, especially in the presence of H2O2 plus Fe(III)-EDTA or Cu(II).”

“In contrast to no effect of hydrogen peroxide (H2O2) alone on the Tg degradation, the inclusion of Cu2+ (30 μM), in combination with 2 mM H2O2 , caused a remarkable degradation of Tg, time- and concentration-dependent.”