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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“This study indicated that H2O2 inhibited PG production by GCs via cAMP pathway, protein kinase C (PKC) and the activities of intracellular calcium , P450scc and StAR protein.”
Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells“It is equally clear that a coupling exists between influx of calcium into cells and their production of reactive oxygen species, such as .O2, H2O2 , and .OH.”
“Likewise, sensor sensitivities to hydrogen peroxide decreased, in the 5-90% range, in the presence of 0.5 mM calcium.”
“ Hydrogen peroxide caused a concentration‐dependent increase in germination that was also reduced in a calcium‐free medium.”
“We note a significant calcium concentration augmentation in HPS solution after 1 month, 6 weeks, and 2 months compared with day 0.”
“The addition of calcium contributed to a reduction in tooth sensitivity, especially when the lower concentration of hydrogen peroxide (20%) was used.”
“In vitro study, the apoptosis rate of cells, the lactate dehydrogenase activities, the hydrogen peroxide , and 8-isoprostane concentrations in the medium all increased in accordance with the increased concentration of calcium supplemented.”
“Oxidative stress induced by H2O2 inhibits osteogenic differentiation by decreasing alkaline phosphatase (ALP) activity, calcium content and mRNA expression levels of osteogenesis marker genes RUNX2 and OSX in hADMSCs.”
“ H2O2 induces changes in intracellular calcium ([Ca(2+)]i) in many cell types and this seems to be at least partially mediated by transient receptor potential melastatin 2 (TRPM2) in cells that express this channel.”
“Here we demonstrate that H2O2 induces a sustained activity of TRPM4, a Ca2+ -activated, Ca2+-impermeant nonselective cation channel resulting in an increased vulnerability to cell death.”
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