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Last Updated: 3 years ago

Possible Interaction: Hydrogen Peroxide and Caffeic Acid

Research Papers that Mention the Interaction

AIM The purpose of this research was to examine the suppressing effect of caffeic acid (CA) on colon cancer cells triggered by an overdose of H2O2 , and molecular mechanisms involved.
Additionally, inducing cells with H2O2 caused a rise in ROS and LPO levels, decrease in TAS level and CAT activity whereas pre-treatment of cells with CA reversed these effects.
Overall, these data revealed that CA can suppress apoptosis in HT-29 cells triggered by an overdose of H2O2 (Fig. 5, Ref.
Bratislavske lekarske listy  •  2020  |  View Paper
Therefore, we investigated the anti-inflammatory mechanism of CHA and CA , both of which inhibited hydrogen peroxide (H2O2)-induced IL-8 transcriptional activity.
Nutrients  •  2017  |  View Paper
In L-02 cells exposed to H2O2, CaA treatment reduced ROS levels, which might have played a protective role.
We found that a low concentration (10 μM) of CaA increased human liver L-02 cell viability, attenuated hydrogen peroxide (H2O2)-mediated decreases in cell viability, and decreased the extent of H2O2-induced DNA double-strand breaks (DSBs).
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  2015  |  View Paper
The phenolic antioxidant caffeic acid inhibits lipoprotein oxidation induced by peroxyl radicals, either in native or photosensitizer-loaded fractions, delays hemolysis of erythrocytes and partially prevents membrane loss of SH groups in ghosts, but not the efflux of K + .
Free radical research  •  2002  |  View Paper
Caffeic acid at 5 microM and sinapic acid at 10 microM protected LDL against oxidation, inhibiting both hydroperoxide formation and the increase of apoprotein negative charge.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2001  |  View Paper
Caffeic acid at the same concentration also inhibits aqueous peroxyl radical-induced oxidation of low-density lipoprotein, sparing alpha-tocopherol.
Clinical science  •  1996  |  View Paper
Furthermore, caffeic acid lowered superoxide ion, hydrogen peroxide and cytochrome P2E1 while increasing the activities of superoxide dismutase, catalase and glutathione S-transferase in the liver of 1,3-dichloro-2-propanol-treated rats.
Human & experimental toxicology  •  2019  |  View Paper
In the lipid peroxidation assays CA acted as both metal-chelator and as hydrogen donor, preventing the deleterious action promoted by lipid-derived peroxyl and alkoxyl radicals.
PloS one  •  2015  |  View Paper
Treatment of rats orally with caffeic acid (20 and 40 mg/kg body weight) resulted in a significant decrease in xanthine oxidase (P < 0.001), lipid peroxidation (P < 0.001), γ-glutamyl transpeptidase (P < 0.01), and H2O2 (P < 0.01).
Molecular and Cellular Biochemistry  •  2011  |  View Paper
Both OGD/recovery and H2O2 increased the phosphorylated p38 MAPK level, which was inhibited by caffeic acid and the ROS scavenger edaravone, but not by MK886 or zileuton.
Journal of neuroscience research  •  2009  |  View Paper
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