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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Arachidonate
Research Papers that Mention the Interaction
“Also, since co-incubation of fatty acid hydroperoxides with arachidonate caused activation of 5-lipoxygenase, we propose that Dnp-C1 increases the peroxide level in PMN which is required for the onset of lipoxygenase activity.”
Involvement of glutathione peroxidase activity in the stimulation of 5-lipoxygenase activity by glutathione-depleting agents in human polymorphonuclear leukocytes.“When the arachidonate release step in prostaglandin (PG) synthesis was bypassed by the addition of free arachidonate to the cell cultures, t-butyl hydroperoxide further stimulated PG synthesis, indicating that the hydroperoxide activates arachidonate conversion to prostaglandins.”
“The formation of the 418 nm-absorbing species was observed immediately after the addition of hydroperoxide to enzyme but only after a 10-s lag period following addition of arachidonate.”
Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase.“Related in vitro studies have shown the followings: (i) the influx of sodium not of proteins is the principal cause of … synthetic capacity of the brain microvessel (MV) is increased simultaneous to edema development (iii) an elevation in the level of hydroperoxides enhances the activities … as the arachidonate cascade ….”
“Preincubation of EC with H2O2 produced a dose-dependent inhibition (inhibitory concentration [IC50] = 35 microM) of PGI2 formation from arachidonate.”
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