Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Hydrogen Peroxide and Andrographolide

Research Papers that Mention the Interaction

Inflammation factors, such as matrix metallopeptidase 13 (Mmp13), tissue inhibitor of metalloproteinase 1 (Timp1), and interleukin‐6 (Il6), were downregulated in the H2O2 group with AP , demonstrating a decrease in the progression of OA.
This study indicates that AP exerts protection effects on oxidative stress via activation of the Keap1–Nrf2–Are pathway in chondrocytes injured by H2O2 , which may be promising for the therapy of OA.
Journal of cellular physiology  •  2018  |  View Paper
The present mechanistic study of andrographolide-mediated effects demonstrated that activated extracellular signal regulated kinase protein and H2O2 production levels were significantly increased by andrographolide.
Experimental and therapeutic medicine  •  2016  |  View Paper