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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Hydrogen Peroxide
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“Tempol augmented whereas LA decreased H2O2 signals.”
Oxidant Generation Predominates Around Calcifying Foci and Enhances Progression of Aortic Valve Calcification“Treatment of mitochondria with H2O2 results in reversible inhibition of KGDH due to glutathionylation of the cofactor, lipoic acid.”
“Pretreatment of cells with alpha-LA prevented these changes induced by TNF-alpha and H2O2.”
“Addition of high concentrations of H2O2 (200 μM) to cells pre-incubated with lipoic acid , however, resulted in cytotoxicity.”
“Enhancement of cellular antioxidant status by pre-incubation of the cells with dehydro-ascorbic acid and lipoic acid , which are reduced intracellularly to ascorbate and dihydrolipoic acid, respectively, afforded protection against caspase-3 activation and apoptosis following addition of H2O2.”
“The administration of LA to endotoxemic rats significantly reduced TBARS, H2O2 , TNF-α, and IL-6 levels and reduced edema in the liver when compared to the LPS group.”
Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver.“Total capacity antioxidant against peroxyl radicals was significantly increased (p<0.05) in the muscle of animals fed with LA after the fourth week.”
“Furthermore, 0.2 mM of H2O2 significantly decreased SOD, GSH-Px, and LDH activity and significant increased MDA level in the lens, but 0.5-2.0 mM of LA blocked the effect of 0.2 mM H2O2.”
“RESULTS A total of 0.2 mM of H2O2 induced obvious cataract formation and apoptosis in lens' epithelial cells, but 0.5-2.0 mM of LA co uld block the effect of 0.2 mM H2O 2 in inducing cataract and apoptosis.”
“Additionally, we found that LA diminished H2O2 levels in the brain.”
“ConclusionsThese data suggest that a decline in H2O2 availability by LA might impede the formation of brain ethanol-derived acetaldehyde by catalase, which results in an impairment of the rewarding properties of ethanol.”
“Pretreatment with LA over the concentration range of 10-1,000 pmol/l protected the insulin effect from inhibition by H2O2.”
“ α-Lipoic acid intake (Thiogamma: 1200 mg daily for 10 days prior to exercise) resulted in a 2-fold elevation of serum H2O2 concentration before exercise, but it prevented the generation of NO, 8-iso, LPO and PC at 20 min, 24 h, and 48 h after exercise.”
THE COMBINATION OF α-LIPOIC ACID INTAKE WITH ECCENTRIC EXERCISE MODULATES ERYTHROPOIETIN RELEASE
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