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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrogen Peroxide
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“Conversely, in NNT-deficient BL/6J mitochondria, H2O2 emission is higher with α-KG than with P/M as substrate, and further potentiated by complex I blockade.”
Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart“We report that TCA cycle metabolites (citrate, isocitrate, α-ketoglutarate , fumarate, malate) individually and quickly inhibit H2O2 release.”
“A study of the isocitrate dehydrogenase reaction in H218O was made possible by the observation that decarboxylation of α-ketoglutarate by H2O2 was faster than spontaneous exchange of the keto group with the medium.”
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