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Last Updated: 2 years ago

Possible Interaction: Hydrogen Peroxide and Allicin

supplement:

Allicin

Research Papers that Mention the Interaction

Results Results of this study revealed that pretreating HUVECs with 5 ng/mL allicin before exposure to H2O2 resulted in increased cell viability and reduced reactive oxygen species generation.
Medical science monitor : international medical journal of experimental and clinical research  •  2017  |  View Paper
Conversely, allicin reverses the effect of H2O2 on cell death, suggesting a role in protecting HUVECs from apoptosis.
We demonstrated that H2O2 activates PARP cleavage, reduces pro-Caspase-3 levels and activates Bax expression; however, allicin inhibits each of these apoptotic signaling indicators.
BMC Complementary and Alternative Medicine  •  2014  |  View Paper
Allicin (0.3–10 μM) pre-incubation could concentration-dependently attenuate the intracellular reactive oxygen species (ROS) increase induced by H2O2 on H9c2 cells.
International journal of food sciences and nutrition  •  2014  |  View Paper
Allicin has been reported to protect against cell apoptosis induced by H2O2 in human umbilical vein endothelial cells.
However, allicin treatment reversed the effect of H2O2 in a dose-dependent manner.
It was also observed that H2O2 exposure significantly decreased Bcl-2 and mitochondrial Cyt C, while it increased Bax and cleaved-caspase-3, which were attenuated by allicin pretreatment.
Experimental and therapeutic medicine  •  2017  |  View Paper
In addition, allicin was demonstrated to be able to significantly ameliorate the repressed phosphoinositide 3-kinase (PI3K)/AKT and cyclic adenosine monophosphate response element-binding protein (CREB)/extracellular-signal-regulated kinase (ERK) signaling pathways by H2O2 , which may also be associated with the anti-oxidative stress effects of allicin.
The results demonstrated that allicin counteracted the reduction of cell viability and induction of apoptosis caused by hydrogen peroxide (H2O2) exposure.
Experimental and therapeutic medicine  •  2016  |  View Paper