Possible Interaction: Hydrocortisone and Yohimbine

“The combined administration of hydrocortisone and yohimbine , however, rendered participants' behavior insensitive to changes in the value of the goal (i.e., habitual).”

“Concomitant yohimbine administration antagonized the effects of alprazolam on blood pressure and attenuated alprazolam-induced changes in cortisol and subjective ratings.”

“Administration of either yohimbine or naloxone caused significant increases in plasma cortisol concentrations over time.”

“Biomarkers, including blood pressure and saliva cortisol, confirmed that yohimbine + hydrocortisone dosing elicited a significant physiological stress response.”

“We pharmacologically manipulated CORT and NA levels in a sample of men (N = 150) and found that isolated hydrocortisone administration promoted prosocial tendencies towards close others, reflected in an altered social discount function, but this effect was offset by concurrent noradrenergic activation brought about by simultaneous yohimbine administration.”

“At the neural level, the combined administration of hydrocortisone and yohimbine reduced the sensitivity of the orbitofrontal and medial prefrontal cortex to changes in outcome value.”

“Our behavioral data confirmed that the simultaneous administration of hydrocortisone and yohimbine renders instrumental behavior insensitive to the outcome devaluation (and thus habitual), whereas hydrocortisone or yohimbine alone have no such effect.”

“Clonidine-induced increase in basal cortisol levels was blocked by the ADRA2A antagonist yohimbine.”

“ Yohimbine caused significant elevation in cortisol and MHPG in both groups.”

“However, we found an interaction of yohimbine and hydrocortisone on selective attention to sad faces.”

“They found that combined administration of hydrocortisone and yohimbine reduced the sensitivity of the orbitofrontal and medial prefrontal cortex to changes in outcome value.”