Possible Interaction: Hydrocortisone and Vitamin D

“Despite controversial results on an association of low vitamin D levels with cortisol and aldosterone overproduction, encouraging in vitro findings have been reported on vitamin D effects in adrenocortical cancer cells.”

“Levels of total 25(OH)D were higher in HC than in patients with IBD (P = 0.01).”

“Because crossreactions between HC and CC have been described, when intramuscular injection is the only administration route possible in a patient sensitised to vitamin B12’ complete allergic investigations with both HC and CC are warranted.”

“Lastly, cortisol also could mediate vitamin D3 signaling to stimulate Ca2+ uptake in zebrafish.”

“64 I. U. of vitamin D2 injected daily was able to prevent the inhibition of bone apposition by 20 mg per kg body weight per day of hydrocortisone.”

“The results imply that vitamin D or its metabolites may compete with hydrocortisone in some cellular mechanisms and support the usefulness of vitamin D supplements in the treatment and the prevention of steroid-induced osteoporosis.”

“ Hydrocortisone , while producing no effect on the high calcium content in the blood of the animals receiving ergocalciferol , attenuates the general toxic action of the latter.”

“ Cortisol at 10-6M significantly inhibited the stimulation of bone resorption produced by vitamin A, prostaglandin E1 and dibutyryl cyclic 3’,5’-adenosine monophosphate in continuous culture but was less effective in inhibiting the response to parathyroid hormone (PTH) or 25-hydroxycholecalciferol (HCC).”

“A small, inverse correlation (r = -0.30, p = 0.04) was detected between 25(OH)D and cortisol concentrations when analyzed as a dichotomous variable only.”