Possible Interaction: Hydrocortisone and Vitamin C

“In patients receiving ascorbic acid , there was a significant increase in serum hydrocortisone concentration.”

“The present study showed that the ascorbic acid and curcumin were more effective than carotenoid and flavonoid, though all provide protection against the genotoxicity of hydrocortisone.”

“When there is a deficiency of ascorbic acid the content of cortisol in the plasma increases.”

“In this small observational study of ICU patients with septic shock, the addition of vitamin C to hydrocortisone therapy did significantly affect hospital mortality or other measures of mortality or organ dysfunction.”

“Furthermore, animals that cannot synthesize vitamin C have significantly elevated cortisol release in response to stress compared with animals that can synthesize vitamin C endogenously (reviewed in [5]).”

“Although the positive results of the CITRIS-ALI study on mortality question the necessity of co-administration of hydrocortisone and thiamine when vitamin C is dosed sufficiently high, notably 66% of patients in CITRIS-ALI study received corticosteroids.”

“The effects of hydrocortisone and ascorbic acid on the final cell density were additive.”

“The present study is an extension of our past study on the clinical use of vitamin … or injection treatment in autoimmune disease and allergy which suggests that the intravenous introduction of vitamin C may enhance the … the endogenous cortisol in such a way as … clinical control of immune disorders.”

“This difference between keloid and normal cells was dependent on the simultaneous presence of ascorbic acid and hydrocortisone.”

“Glucose-cysteine, hydroquinone, adrenaline, ascorbic acid , aspirin and butazolidin inhibit both the reduction of Δ4-3 ketone and the degradation of the side-chain in the metabolism of hydrocortisone in vitro.”