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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrocortisone
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“The administration of hydrocortisone to adrenalectomized vitamin B6-deficient rats induced expression of hepatic cAST mRNA and the induction was suppressed by the simultaneous administration of pyridoxine.”
Pyridoxal 5'-phosphate modulates expression of cytosolic aspartate aminotransferase gene by inactivation of glucocorticoid receptor.“Addition of 2 mM and 5mM pyridoxal-5'-P in the medium (Waymouth's MB752/1) resulted in 4- and 12-fold increase of its concentration in the glands incubated with insulin, prolactin, and hydrocortisone.”
“These results suggest that in response to hydrocortisone administration a redistribution of pyridoxal phosphate occurs amongst pyridoxal phosphate-dependent enzymes due to the increase of the rate of biosynthesis of some of them.”
“For example, the induction of cytosolic aspartate aminotransferase (cAspAT) in rat liver by hydrocortisone is suppressed by the administration of pyridoxine.”
Modulation of gene expression by vitamin B6
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