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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrocortisone
supplement:
Vitamin A
Research Papers that Mention the Interaction
“Cell surface membrane-active agents, such as chloroquine, hydrocortisone and chlorpromazine inhibited cytotoxicity, while vitamin A caused enhancement.”
Lectin-dependent neutrophil-mediated cytotoxicity. II. Possible mechanisms.“Furthermore, vitamin A induces lysosomes to release their hydrolytic enzymes both in vitro24�25 and in vivo,24 both effects being inhibited by hydrocortisone which stabilizes lysosomal membranes.”
“The simultaneous administration of cortisol and vitamin A to albino rats resulted in intense bone absorption not observed with vitamin A alone.”
“ Vitamin A status , based on serum retinol (P = .001) and RDR (P < .001) values, was lower in the HC than in the PH and PHC.”
Vitamin A repletion in thoroughbred mares with retinyl palmitate or beta-carotene.“The data on the enzyme activities in the groups simultaneously fed on vitamin A and cortisol may indicate an additive effect of these compounds.”
“The effects of vitamin A on insulin release were dissociated in part from those effects on glucose oxidation, in that hydrocortisone opposed the effect of vitamin A on insulin release but not on glucose oxidation.”
“The authors explain this effect by an antagonistic influence of cortisol and vitamin A on inflammation and by this on the amount of collagen.”
“ Cortisol at 10-6M significantly inhibited the stimulation of bone resorption produced by vitamin A , prostaglandin E1 and dibutyryl cyclic 3’,5’-adenosine monophosphate in continuous culture but was less effective in inhibiting the response to parathyroid hormone (PTH) or 25-hydroxycholecalciferol (HCC).”
“… hydrocortisone … vitamin A on the cartilage of embryonic bone explants.7 It was then shown that the lysosome-rich fraction taken from the livers of rats … that hydrocortisone had the property of stabilizing lysosomes against several forms of injury, including excess vitamin A. However, two reports contradictory to this”
“The retardative action of hydrocortisone on the changes produced by excess vitamin A in skeletal tissue in culture, contrasts sharply with the strongly additive effect of the two agents on the skeleton in the intact animal (Selye, 1958).”
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