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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrocortisone
supplement:
St John's Wort
Research Papers that Mention the Interaction
“The urinary ratio of 6beta-hydroxycortisol to cortisol , which reflects CYP3A4 activity, also increased after dosing with SJW (ratio; 2.1 (95%CI 0.85-3.4)).”
Drug interaction between St John's Wort and quazepam.“Results show that HP significantly reduced corticosterone and cortisol in brain frontal cortex tissue.”
“Studies have suggested that HP might alter brain cortisol and corticosterone through its effect on multidrug transporter glycoprotein (Pgp).”
Sub-chronic treatment with an extract of Hypericum perforatum (St John's wort) significantly reduces cortisol and corticosterone in the rat brain
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