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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Hydrocortisone and St John's Wort

Research Papers that Mention the Interaction

The urinary ratio of 6beta-hydroxycortisol to cortisol , which reflects CYP3A4 activity, also increased after dosing with SJW (ratio; 2.1 (95%CI 0.85-3.4)).
British journal of clinical pharmacology  •  2004  |  View Paper
Results show that HP significantly reduced corticosterone and cortisol in brain frontal cortex tissue.
Studies have suggested that HP might alter brain cortisol and corticosterone through its effect on multidrug transporter glycoprotein (Pgp).
European Neuropsychopharmacology  •  2002  |  View Paper